Jusqu’où explorer une hyperéosinophilie associée à des manifestations pulmonaires ?

An eosinophilic inflammatory response is associated with various lung diseases. Progress in the pathophysiology of certain diseases with hypereosinophilia, called idiopathic, has led to their being clarified, for example, the so-called idiopathic hypereosinophilic syndromes. In children, after eliminating parasitic infection, the diagnosis is guided by the patient's clinical status (association with asthma, changes in the general state of health, extrarespiratory symptoms, drugs). Bronchoscopy with broncho-alveoalar lavage and biopsy that show alveolar and parenchymal eosinophilia and a thoracic CT can narrow the diagnosis and determine the subsequent laboratory studies to be done. Whatever the cause, prolonged hypereosinophilia carries with it a risk of systemic pathology, especially cardiac, especially if the eosinophils are activated.