脑心通胶囊联合阿司匹林治疗急性心肌梗死的临床研究

目的 探讨脑心通胶囊联合阿司匹林治疗急性心肌梗死的临床研究。方法 选取2019年9月—2021年1月阜阳市肿瘤医院心血管内科收治的86例急性心肌梗死患者作为研究对象，按照治疗方法将86例患者分为对照组和观察组，各有43例。对照组口服阿司匹林肠溶片，100 mg/次，1次/d。观察组在对照组的基础上口服脑心通胶囊，0.8 g/次，3次/d。两组均连续治疗4周。观察两组患者的临床疗效，同时比较两组治疗前后的纤维蛋白原、血浆黏度、全血高切黏度、D-二聚体和红细胞压积（HCT）水平，检测两组左室射血分数（LVEF）、心搏出量（CO）水平。运用WHO生活质量量表（WHOQOL）对患者的生活质量进行评估。记录两组患者不良反应的发生情况。结果 治疗后，观察组患者的总有效率为95.35%，显著高于对照组的81.40%，组间比较差异有统计学意义（P<0.05）。治疗后，两组的LVEF、CO均显著升高（P<0.05）；治疗后，观察组的LVEF、CO显著高于对照组，差异有统计学意义（P<0.05）。治疗后，两组纤维蛋白原、血浆黏度、全血高切黏度、D-二聚体显著降低，HCT水平显著升高（P<0.05）；治疗后，观察组的纤维蛋白原、血浆黏度、全血高切黏度、D-二聚体和HCT水平显著优于对照组，差异有统计学意义（P<0.05）。治疗后，两组的WHOQOL评分均显著降低（P<0.05），以观察组降低更明显（P<0.05）。两组的药物不良反应的发生率无明显差异。结论 脑心通胶囊联合阿司匹林可提高急性心肌梗死的疗效，改善患者血液流变学和心功能，增强生活质量，具有良好的疗效。

Clinical study of Naoxintong Capsules combined with aspirin in treatment of acute myocardial infarction

Objective To explore the clinical study of Naoxintong Capsules combined with aspirin in treatment of acute myocardial infarction. Methods A total of 86 patients with acute myocardial infarction admitted to Department of Cardiovascular Medicine (Interventional Treatment Ward), Fuyang Cancer Hospital from September 2019 to January 2021 were selected as the research subjects. According to the treatment methods, the 86 patients were divided into control group and observation group, with 43 patients in each group. Patients in the control group were po administered with Aspirin Enteric-Coated Tablets, 100 mg/time, once daily. Patients in the observation group were po administered with Naoxintong Capsules on the basis of control group, 0.8 g/time, 3 times daily. Both groups were treated continuously for 4 weeks. The clinical efficacy of two groups was observed, and the levels of vitaminogen, plasma viscosity, whole blood high-cut viscosity, D-dimer and hematocentre (HCT) before and after treatment were compared between two groups, and the levels of LVEF and CO were detected between two groups. The quality of life of the patients was evaluated by the WHO Quality of Life Scale (WHOQOL). The incidence of adverse reactions in two groups was recorded. Results After treatment, the total effective rate of observation group was 95.35%, which was significantly higher than 81.40% of control group, and the difference between groups was statistically significant (P < 0.05). After treatment, LVEF and CO in two groups were significantly increased (P < 0.05). After treatment, LVEF and CO in the observation group were significantly higher than those in the control group, with statistical significance (P < 0.05). After treatment, fibrinogen, plasma viscosity, whole blood high-cut viscosity, and D-dimer were significantly decreased in both groups, while HCT level was significantly increased (P < 0.05). After treatment, the levels of fibrinogen, plasma viscosity, whole blood high-cut viscosity, D-dimer and HCT in the observation group were significantly better than those in the control group, with statistical significance (P < 0.05). After treatment, the WHOQOL scores of both groups were significantly decreased (P < 0.05), and the decrease was more obvious in the observation group (P < 0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups. Conclusion Naoxintong Capsules combined with aspirin can improve the curative effect of acute myocardial infarction, improve hemorheology and cardiac function of patients, enhance the quality of life, has a good curative effect.