HLA DOA-DQB HAPLOTYPES IN A SWEDISH POPULATION

Samples from 94 Swedish blood donors were analysed for HLA-DQA1 and -DQB1 alleles by the PCR-SSO technique used in the XIth Histocompatibility Workshop. Seven DQA1 and 12 DQB1 alleles were identified and a total of 17 haplotype combinations were found deduced from the most probable allele combinations. Frequencies calculated from these haplotypes were compared to those calculated from the phenotypes according to Mattiuz et al. (1970). There was no significant difference in the frequencies of the 17 haplotype combinations deduced. Eight haplotype combinations had exactly the same frequencies and four had approximately the same frequencies independent of the calculation method used. The DQA1*0301-DQB 1*0302, DQA1*0501-DQB1*0201, DQA1* 0101-DQB1* 0501, and DQA1*0102-DQB1*0602 were the most frequent haplotypes with frequencies over 0.130.