Molecular study of 45,X conceptuses: Correlation with clinical findings

The parental origin of the single X in 45 cases (40 liveborns and 5 fetuses) with a 45, X karyo-type was studied using polymorphic DNA probes. The single X was paternal in origin (X^p) in 10 cases (22.2%) and maternal (X^m) in 35 cases (77.8%). Y chromosome material was detected in 1 out of the 35 cases with a 45, X^m constitution. Analysis of parental ages and clinical data of the patients with respect to the origin of the single X revealed no significant differences between the origins.