| Abstract: | Intraperitoneal injection of cholecystokinin (CCK) A-type receptor antagonists, L-364,718 and CR 1409, caused dose-dependent memory impairments in passive and active avoidance responses and in Morris water pool test in rats. These antagonist effects were significant at a dose of 1 mg/kg, while with proglumide, 50–100 mg/kg were required to produce a similar memory deficit. The results suggest that loss of biologically active CCK octapeptide (CCK-8), not only in the brain but also in the peripheral tissues, causes memory impairmets in rats. © 1992 Wiley-Liss, Inc. |
