Rolipram inhibits airway microvascular leakage induced by platelet-activating factor,histamine and bradykinin in guinea-pigs |
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Authors: | JOS L. ORTIZ,JULIO CORTIJO,JOS M. VALL S,JOSEP BOU,ESTEBAN J. MORCILLO |
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Affiliation: | JOSÉ L. ORTIZ,JULIO CORTIJO,JOSÉ M. VALLÉS,JOSEP BOU,ESTEBAN J. MORCILLO |
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Abstract: | Abstract— Rolipram (0·1–1000 μg kg?1, i.v.) reduced the increase in microvascular permeability induced by platelet-activating factor (PAF; 50 ng kg?1, i.v.) at different sites of the guinea-pig airways. Rolipram (1–100μg kg?1, i.v.) inhibited histamine (30μg kg?1, i.v.)-and bradykinin (0·3 μg kg, i.v.)-induced airway microvascular leakage. These effects of rolipram were obtained at doses which inhibit histamine (7–20 μg kg?1 min?1)-induced bronchoconstriction (IC50 = 3 ± 1 μg kg, i.v.) without depressing arterial blood pressure in the guinea-pig. Aminophylline (50 mg kg?1) did not change the effect of PAF. The anti-exudative effect of rolipram is of potential therapeutic value in asthma. |
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