In-vitro permeation of some β-blockers across the hairless mouse skin

Abstract— To support the development of a suitable transdermal dosage form for β-blockers, in-vitro, skin permeation studies of nine β-blockers were conducted at 37°C across the excised abdominal skin of hairless mouse mounted on the receptor compartment of a two-chambered Valia-Chien glass diffusion cell. The drugs varied in lipophilicity, whereas pK_a values were comparable. Permeability coefficients were calculated from the steady-state flux values. Agreement was found between the permeability coefficient and the drug lipophilicity, expressed as the octanol-bufter distribution coefficient.