Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering |
| |
Authors: | Quen Oak Tang Clare Francesca Carasco Zakareya Gamie Nectarios Korres Athanasios Mantalaris Eleftherios Tsiridis |
| |
Affiliation: | Aristotle University Medical School, Academic Orthopaedic and Trauma Unit, University Campus , 54 124 Thessaloniki , Greece. |
| |
Abstract: | Introduction: With an ageing population, the prevalence of osteoarthritis (OA) has increased. Mesenchymal Stem Cells (MSCs) have been proposed to be an attractive alternative candidate in the tissue engineering of articular cartilage primarily due to its abundant source, reduced cartilage donor site morbidity, and strong capacity for proliferation and potential to differentiate toward a chondrogenic phenotype. Areas covered: A current overview of human, in vivo, and in vitro evidence on the use of MSCs in cartilage tissue engineering. Expert opinion: We demonstrate robust evidence that MSCs have the potential to regenerate articular cartilage. We also identify the complexity of designing a suitable preclinical model and the challenges in considering its clinical application such as type of MSC, scaffold, culture construct and the method by which growth factors are delivered. Of great interest is further characterization of the factors that may prevent MSC-derived chondrocytes to undergo premature hypertrophy and to understand what enables the terminal developmental pathway for permanent hyaline cartilage regeneration. Despite this, there is an abundance of evidence suggesting that MSCs are a desirable cell source and will have significant impact in tissue engineering of cartilage in the future. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|