血浆同型半胱氨酸与脑梗死的相关性分析

目的探讨血浆同型半胱氨酸(Hcy)及血脂水平与脑梗死的关系。方法对90例急性脑梗死患者在起病3 d内检测其血浆同型半胱氨酸(Hcy)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)水平,以同期门诊32例健康体检者为对照组,分析血浆同型半胱氨酸及血脂水平与脑梗死发病的相关性。结果急性脑梗死组血浆Hcy、TG、TC水平明显高于对照组,差异有统计学意义(P<0.05);Hcy、TC和高血压病为急性脑梗死发病的独立危险因素。结论高同型半胱氨酸血症是脑梗死患者的独立危险因素,血浆同型半胱氨酸可作为常规检查,在预防和减少脑梗死的发病中有重要意义。

Correlation analysis of plasma homocysteine with ischemic stroke

Objective To investigate the relationship between plasma homocysteine（Hcy）,lipids and ischemic stroke.Methods The plasma levels of Hcy,triglyceride（TG）,total cholesterol（TC）,high density lipoprotein-cholesterol（HDL-C） and low density lipoprotein-cholesterol（LDL-C） of 90 patients with acute ischemic stroke and 32 age and gender matched controls were detected respectively.The relationship between Hcy,lipids and ischemic stroke was analyzed.Results The plasma levels of Hcy,TG,TC in acute ischemic stroke group were significantly higher than those in control group.Hcy,TC and hypertension were independent risk factors of ischemic stroke.Conclusion Hyperhomocysteinemia（HHcy） is an independent risk factor of ischemic stroke.The Hcy level can serve as a kind of regular examination,which is of great importance in preventing ischemic stroke and reduce its morbility.