肝纤维化患者临床检验血清学指标检测分析

目的研究肝纤维化患者临床检验血清学指标的临床意义。方法回顾性分析信阳市中心医院自2009年1月至2011年1月收治的肝纤维化患者162例,检测凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、血浆凝血酶时间（TT）、血浆纤维蛋白原（FIB）、D-二聚体（D-D）的值。结果重度、中度肝纤维化与正常组比较,PT、APTT、TT、FIB、D-D值差异均有统计学意义（P〈0.05或〈0.01）;轻度肝纤维化与正常组比较,PT、TT、D-D值差异均有统计学意义（P〈0.05）。结论肝纤维化患者检测PT、APTT、TT、FIB和D-D值的变化,可从不同角度客观准确地评价肝纤维化患者的病情及凝血功能状况,值得临床推广。

Detection analysis of clinical laboratory serological index in hepatic fibrosis patients

Objective To study the clinical significance of serological test index in patients with hepatic fibrosis.Methods The clinical data of 162 patients with hepatic fibrosis from January 2009 to January 2011 in Xinyang Central Hospital were retrospectively analyzed.The levels of prothrombin time(PT),activate part thromboplastin time(APTT),thrombin time(TT),plasma fibrinogen(FIB),D-dimer(D-D) were detected.Results There were significant differences in the levels of PT,APTT,TT,FIB,D-D between the severe,moderate hepatic fibrosis group and normal group(P<0.05 or P<0.01),and there were significant differences in the levels of PT,TT,D-D between the mild hepatic fibrosis group and the normal group(P<0.05).Conclusion The change of levels of PT,APTT,TT,FIB and D-D in patients with hepatic fibrosis,can be used to evaluate the disease and blood clotting function at different angles objectively and accurately,deserve clinical appcication.