PCT、hs-CRP及WBC联合检测在新生儿败血症早期诊断中的临床应用

目的探讨降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)水平、白细胞计数(WBC)在新生儿败血症早期诊断中的应用价值。方法采用电化学发光法测定血清中PCT水平,采用免疫比浊法测定血清中hs-CRP水平及两者的动态变化,用Sysmex-1800i检测WBC。结果新生儿败血症重症组血清PCT和hs-CRP水平在治疗前明显升高,与轻度组比较差异有统计学意义(P<0.05),轻度组与对照组比较差异亦有统计学意义(P<0.05)。经抗菌药物有效治疗后,PCT和hs-CRP水平与治疗前比较差异有统计学意义(P<0.05)。WBC计数在新生儿败血症组和对照组中比较差异无统计学意义。结论血清PCT和hs-CRP联合检测在新生儿败血症的早期诊断中有一定价值,动态检测PCT和hs-CRP水平有助于评估治疗效果,协助临床判断病情的转归。

Cinical application of combined detection of serum PCT,hs-CRP and WBC in the early diagnosis of neonatal sepsis

Objective To investigate the application value of serum procalcition(PCT),hs-CRP and WBC in the early diagnosis of neonatal sepsis.Methods PCT was determined by ECLIA and hs-CRP was determined by nephelometry,WBC was determined by Sysmex-1800i.Results The levels of PCT and hs-CRP in group of serious degree increased significantly,there was statistical significance compared with group of light degree(P<0.05),and there was significanct difference between group of light degree and control group(P<0.05).There were significanct differences in PCT and hs-CRP levels between before and after the antibiotic treatment.There was no significant differenice in the WBC count between group of neonatal sepsis and coutrol group.Conclusion The combined detection of serum PCT and hs-CRP has value in the early diagnosis of neonatal sepsis.Monitoring dynamically the levels of PCT and hs-CRP can help to evaluate the curative effect.