| 诺氟沙星滴眼液点眼的眼内组织分布及其药代动力学研究 |
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| 引用本文： | 杨淑群,周远大.诺氟沙星滴眼液点眼的眼内组织分布及其药代动力学研究[J].重庆医科大学学报,1993,18(3):194-198. |
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| 作者姓名： | 杨淑群 周远大 |
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| 作者单位： | 重庆医科大学第二医院眼科
(杨淑群)，重庆医科大学第一医院临床药理研究室
(周远大，何海霞，李远宗)，重庆医科大学第一医院临床药理研究室(朱治本) |
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| 摘 要： |
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| 关 键 词： | 诺氟沙星 滴眼液 药代动力学 |
DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE |
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| Yang Shuqun,et al Dept of Ophthalmology The Second Hospital.DISTRIBUTION AND PHARMACOKINETICS OF TOPICALLY APPLIED NORFLOXACIN EYEDROP IN THE RABBIT EYE[J].Journal of Chongqing Medical University,1993,18(3):194-198. |
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| Authors: | Yang Shuqun Dept of Ophthalmology The Second Hospital |
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| Abstract: | The intraocular penetration and pharmacokinetio analysis of norfloxacin were dbserved.The concentration of norfloxacin was measured successflly by high performance liquid chromatography (HPLC) after topically applying 0.3% norfloxacin eyedrops to rabbit eyes. The results showed that norfloxacin could rapidly penetrate into rabbit ocular tissues. The concentration order was cornea, iris-ciliary body, lens, vitreous body, aqueous humour. Among all tissues concentration of norf loxacin in cornea was the highest. The permeability of norfloxacin in cornea epithelial barrier(Kep)was 2.91 10-'.The half-life ( Tl/2)of tha tissue concentration in lacritnal fluid, cornea, aqueous humour, iris-ciliary body, lens and vitreous body was 2.99h, 0.69h, 1.82h, 1.18h, 1.23h and O.Slh, respectively. The peak conc-entration(Cmax) of norfloxacin in the tissues was 9.18p.g/g in cornea,0.35ng/ml in aqueous humour, 5.l7|ig/g in iris-ciliary body, 1.36|ig/g in lens and 0.59ug/ml in vitreous. The experiment indicates that norfloxacin can maintain higher concentration in lacrimal fluid and cornea. Therefore, it is the first choice of drugs for treatment of superficial ocular infection |
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| Keywords: | High-performance Liquid Chromatography (HPLC) Eyedrops Norfloxaein Pharmacokinetios |
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