GnRH受体在子宫内膜的表达与临床意义

促性腺激素释放激素在体内的生理调节功能是由促性腺激素释放激素受体介导的。促性腺激素释放激素与受体的结合具有高度特异性。其受体除位于下丘脑 垂体 性腺轴外 ,在机体其他组织 ,尤其是外周性腺组织中也有分布。近年来研究发现 ,子宫内膜异位症患者的异位内膜组织表面也有促性腺激素释放激素受体表达 ,推测促性腺激素释放激素可能通过其受体介导 ,以旁分泌或自分泌的机制作用于靶细胞 ,对异位内膜细胞的种植和生长直接产生作用。研究子宫在位与异位内膜组织促性腺激素释放激素受体的表达 ,有助于进一步探讨促性腺激素释放激素受体在子宫内膜异位症发病中的作用 ,以更有效地利用促性腺激素释放激素类似物治疗子宫内膜异位症

Expression of GnRH receptor in human eutopic and ectopic endometrium and its clinical significance

In human body, physiological functions of GnRH(gonadotropin-releasing hormone)is mediated by GnRH receptor(GnRHR). GnRH binds to its receptor in high specificity. GnRHR distributes not only in hypothalamic-pituitary-gonadal axis but also in several extrapituitary organs, such as placenta, gonads and mammary glands. Recent studies showed that GnRHR is also expressed in surface of human ectopic endometrial cells in endometriosis, and inferred that mediated by its receptor, GnRH may act into the target celles to exert a direct modulating effect on implantation and growth of ectopic endometrial cells in paracrine/autocrine way. Studies on expression of GnRHR in eutopic and ectopic endometrium will contribute to learn the role of GnRHR in occurrence of endometriosis so as to use GnRH analogues to treat the disease.