| Institution: | (1) Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong, Jongro-gu, 110-744 Seoul, Korea;(2) Department of Internal Medicine, Seoul Municipal Boramae Hospital, 395 Sindaebang-2-dong, Dongjak-gu, 156-012 Seoul, Korea;(3) Department of Laboratory Medicine, Seoul Municipal Boramae Hospital, 395 Sindaebang-2-dong, Dongjak-gu, 156-012 Seoul, Korea;(4) Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, 463-707 Gyeonggi-do, Korea |
| Abstract: | We describe a 55-year-old woman who presented with pancytopenia with a normocytic and normochromic anemia which was progressive despite conventional treatments such as folic acid, vitamin B6, and oxymetholone. Her physical findings and history of a previous massive postpartum hemorrhage suggested Sheehan s syndrome, and the pituitary hormonal studies revealed panhypopituitarism. After 4 months of thyroxine and glucocorticoid replacement therapy, her pancytopenia and bone marrow hypoplasia recovered completely. Pancytopenia is a rare manifestation of a hormonal abnormality, but hematologists need to be aware of panhypopituitarism as a differential diagnosis when women showing features of hypopituitarism present with pancytopenia because it can be reversed with adequate hormone replacement.This study was supported by a grant from Seoul Municipal Boramae Hospital Clinical Research Fund (2002) |
