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Monoclonal antibodies to intermediate filament proteins: Diagnostic specificity in orbital pathology |
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| Authors: | Thomas D Lindquist MD PhD James C Orcutt MD PhD Allen M Gown MD |
| Institution: | a Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, USA b Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA |
| Abstract: | Intermediate filaments derived from different cell types are antigenically distinct. Monoclonal antibodies to human intermediate filament proteins can, therefore, be used as tissue-specific reagents capable of distinguishing cell type in poorly differentiated neoplasms. We report a case demonstrating the specificity of antiintermediate filament protein antibodies in establishing a difficult orbital diagnosis of esthesioneuroblastoma. |
| Keywords: | Author Keywords: esthesioneuroblastoma hybridoma techniques immunohistochemistry intermediate filaments monoclonal antibodies |
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