清醒大鼠动脉压力感受性反射的功能研究

本文综述本室近10年来对清醒自由活动大鼠动脉压力感受性反射(ABR)的功能性研究.首先,建立了ABR对血压的控制(ABR-BP)的测量方法.ABR-BP是与用经典方法测量的ABR功能(ABR-HP)不同的成份.其次,我们的研究表明ABR功能与高血压的器官损伤有关.损毁ABR功能可导致严重的器官损伤.该损伤的机制与血压波动性增高、肾素血管紧张素系统激活有关.酮色林能改善ABR功能.基于对酮色林研究的结果,我们提出改善ABR功能可作为改善某些心血管疾病预后的新策略.最后,提到了我们正在进行中的自发性ABR功能缺陷大鼠的培育.

Arterial baroreflex function in conscious rats

Arterial baroreflex (ABR) is a very important mechanism in the regulation of cardiovascular activities. As ABR function is largely inhibited by anesthesia, its measurement in conscious animal becomes important. The present review summarizes the works concerning ABR function in conscious rats completed in our department in the last 10 years. Firstly, a new method was established to measure arterial baroreflex-blood pressure control (ABR-BP). ABR-BP and baroreflex sensitivity measured with classic method are two different parts of the ABR function. Secondly, it was proposed that ABR function predicted the end-organ damage in hypertension. Thirdly, interrup-tion of ABR induced severe end-organ damages. Increased blood pressure variability (BPV) and activation of renin angiotensin system were involved in the mechanisms underlying organ damages in sinoaortic denervation (SAD) rats. Fourthly, we propose that amelioration of ABR function may serve as a new strategy for improving the prognosis of cardiovascular diseases. Ketanserin improved the impaired ABR function in SHR. Finally, the possi-bility to develop a strain of rats with spontaneous deficiency on ABR function is mentioned.