脑梗死患者血脂水平与颈动脉内中膜厚度的相关性分析

目的 探讨脑梗死(CI)患者血脂水平与颈动脉内中膜厚度(CIMT)的相关性.方法 测定120例CI患者(CI组)和120例神经科非CI患者(对照组)CIMT、血浆氧化低密度脂蛋白(ox-LDL)及血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B (Apo-B)、脂蛋白(a) LP(a)]水平,并进行相关分析.结果 CI组TC、TG、Apo-B、LP(a)和ox-LDL水平高于对照组(P＜ 0.01);CI组CIMT检测结果 为1.1±0.32 mm,高于对照组的0.8±0.54 mm(P＜0.01);CI组TC、TG、LDL-C、Apo-B 、LP(a)、ox-LDL与CIMT呈正相关(P＜0.01),HDL-C、Apo-A1与CIMT呈负相关(P＜0.01).结论 脂代谢异常与CI患者动脉粥样硬化密切相关;CI患者体内可能存在脂质过氧化反应;抑制脂质过氧化,减少ox-LDL的生成有助于预防和治疗CI.

Relationship between lipidemia and carotid intima-media thickness in patients with cerebral infarction

Objective To investigate the relationship between lipidemia and carotid intima-media thickness(CIMT) in patients with cerebral infarction(CI).Methods CIMT,plasma oxidized low-density lipoprotein(ox-LDL)level and serum level of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein-cholestero(LDL-C),high density lipoprotein-cholestero(HDL-C),apoprotein A1(Apo-A1),apoprotein B(Apo-B) and lipoprotein(a) were detected in 120 cases of patients with CI(CI group) and 120 non-CI subjects(control group).Results Levels of TC,TG,Apo-B,LP(a) and ox-LDL in CI group were higher than those in control group(P< 0.01).CIMT of CI group was 1.1±0.32 mm,which was higher than 0.8±0.54 mm of control group(P< 0.01).In CI group,TC,TG,LDL-C,Apo-B,LP(a) and ox-LDL were positively correlated with CIMT(P<0.01),but HDL-C and Apo-A1 were negatively correlated with CIMT(P<0.01).Conclusion There could be certain correlation between abnormal lipid metabolism and atherosclerosis in patients with CI.There could be peroxidatic reaction of lipid in patients with CI.Inhibition of lipid preoxidation to reduce the production of ox-LDL might play an important role for the prevention and therapy of CI.