分离自肺部感染患者呼吸道标本的致病菌分布及其耐药谱分析

目的 了解肺部感染患者病原菌的分布及耐药性.方法 对临床分离致病菌1020株,进行鉴定和药敏试验,对其结果进行分析.结果 1 020株病原菌中,革兰阳性球菌248株(24.3%),以葡萄球菌为主;革兰阴性杆菌588株,以铜绿假单胞菌(12.0%),克雷伯菌(11.0%),大肠埃希菌(7.8%),不动杆菌(7.1%)为主.革兰阳性球菌对青霉素和氨苄西林高度耐药;革兰阴性杆菌对亚胺培南耐药率最低,其次是哌拉西林/他唑巴坦,但对部分抗菌药物产生多重耐药.结论 引起肺部感染病原菌以革兰阴性杆菌为主,在治疗肺部感染时应对病原菌进行分离检测,并根据药敏试验结果合理选用抗菌药物,减少耐药菌株产生.

Distribution and drug resistance spectrum analysis of pathogenic bacteria isolated from respiratory tract specimen of patients with lung infection

Objective To understand the distribution and drug resistance of pathogenic bacteria in patients with lung infection.Methods 1 020 strains of clinically isolated pathogenic bacteria were identified and tested for drug resistance,and all results were analyzed.Results Among 1 020 strains of pathogenic bacteria,248 strains(24.3%) were gram positive coccus,most of which were staphylococci,588 strains were gram negative bacilli,in which Pseudomonas aeruginosa,klebsiella,Escherichia coli and Acinetobacter occupied 12.0%,11.0%,7.8% and 7.1%.Gram positive cocci were highly resistant to penicillin and ampicillin.Gram negative bacilli were resistant most sensitive to Imipenem,followed by piperacillin-Tazuobatan,but were with multi-drug resistance to part of antimicrobials.Conclusion Gram negative bacilli were the most common pathogenic bacteria,causing lung infection.For treatment of lung infection,pathogenic bacterial should be isolated and detected for drug resistance,and the results of susceptibility test should be referred for rational usage of antimicrobials to avoid the formation of drug resistance strains..