长期饮酒者戒酒前后血清指标检测结果分析

目的 探讨长期问题饮酒患者戒酒前后血清生化指标变化趋势.方法 对53例长期饮酒并成功戒酒的患者戒酒前和戒酒3、6、12周时血清铁蛋白(FER)、糖缺失转铁蛋白(CDT)、转铁蛋白(Tf)、γ-谷氨酰转肽酶(GGT)、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)水平,并计算CDT在Tf中所占百分比(CDT%).对结果 进行统计学分析.结果 随着患者戒酒时间的延长,血清CDT、CDT%、GGT水平下降(P＜0.05).与戒酒前相比,戒酒6周和戒酒12周血清FER水平降低(P<0.05).结论 长期饮酒者血清GGT、CDT、CDT%、FER水平随戒酒时间延长降低,但FER水平下降速度缓慢,GGT水平易受其他因素影响.因此,血清CDT及CDT%水平可以用于问题饮酒患者戒酒情况的长期监控.

Level changes of serum indicators in long-term alcohol users before and after alcohol withdrawal

Objective To explore the level changes of serum biochemical indicators in long-term alcohol users before and after alcohol withdrawal.Methods Serum levels of ferritin(FER),carbohydrate-deficient transferrin(CDT),transferrin(Tf),γ-glutamyl transpeptidase(GGT),alanine aminotransferase(ALT)and aspartate aminotransferase(AST) were detected in 53 cases of long-term alcohol users before and 3,6 and 12 weeks after alcohol withdrawal.The CDT% level was calculated.And all results were statistically analyzed.Results Serum levels of CDT,CDT% and GGT gradually decreased with the prolonging of alcohol withdrawal(P<0.05).Compared with before alcohol withdrawal,serum level of FER decreased 6 weeks after alcohol withdrawal(P<0.05).Conclusion Serum levels of CDT,CDT%,GGT and FER could be gradually decreased with the prolonging of alcohol withdrawal,but the rate of decay of FER might be slow and serum level of GGT might be influenced by other factors.Therefore,serum levels of CDT and CDT% could be used for long-term monitoring of alcohol withdrawal in alcohol users.