血浆高敏C-反应蛋白对儿童紫癜性肾炎病理分级与临床分型的评估价值

目的探讨血浆高敏C-反应蛋白对紫癜性肾炎病理分级与临床分型的评估价值.方法 选择190例确诊为紫癜性肾炎患儿及60例健康儿童作为对照组,检测两组血浆高敏C-反应蛋白水平,同时评估紫癜性肾炎患儿病理分级和临床分型.采用Spearman秩相关分析评估紫癜性肾炎患儿血浆高敏C-反应蛋白水平与病理分级及临床分型的关系.结果 紫癜性肾炎患儿血浆高敏C-反应蛋白水平明显高于对照组(6.5±3.2 mg/L,0.9±0.2 mg/L,P<0.05);随着患儿病理分级与临床分型加重,其血浆高敏C-反应蛋白水平也逐渐升高,相关分析结果提示血浆高敏C-反应蛋白水平和病理分级及临床分型呈正相关,相关系数分别为0.854(P<0.05)和0.892(P<0.05).结论 紫癜性肾炎患儿血浆高敏C-反应蛋白与其病理分级和临床分型存在明显相关,血浆高敏-C反应蛋白水平在一定程度上能够反应紫癜性肾炎肾组织病理改变及临床病情严重性.

Predictive value of plasma level of high sensitivity C-reactive protein on the pathological grade and clinical classification of henoch-schonlein purpura nephritis in children

Objective To investigate the predictive value of plasma level of high sensitivity C-reactive protein (hs-CRP) on the pathological grade and clinical classification of henoch-schonlein purpura nephritis (HSPN) in children.Methods 190 patients with definite diagnosis of HSPN(HSPN group) and 60 healthy children(control group) were enrolled and plasma level of hs-CRP of these two groups was evaluated. Pathological grade and clinical classification were evaluated in HSPN group. Spearman correlation analysis was applied to evaluate the relationship between plasma level of hs-CRP and pathological grade and clinical classification.Results Compared with control group, plasma level of hs-CRP significantly elevated in HSPN group (6.5±3.2 mg/L vs 0.9±0.2 mg/L,P<0.05).Pathological grade and clinical classification gradually progressed accompanied with the increasing of plasma level of hs-CRP in HSPN group. Both pathological grade and clinical classification were positively correlated with plasma level of hs-CRP, as indicated by correlation analysis, and the correlation coefficient was 0.854(P<0.05) and 0.892(P<0.05) respectively.Conclusion Pathological grade and clinical classification of HSPN were apparently correlated with plasma level of hs-CRP, and the pathological changes of renal tissue and the severity of clinical presentation could be indicated by the plasma level of hs-CRP in children with HSPN.