老年细菌性阴道炎患者致病菌分布与耐药性调查与分析

目的 分析老年细菌性阴道炎患者致病菌分布及耐药现状,为临床治疗提供依据.方法 回顾性分析2008～2010年于本院确诊的老年细菌性阴道炎患者送检的阴道分泌物标本致病菌分离、培养、鉴定及药敏试验结果.结果 主要病原菌依次为凝固酶阴性葡萄球菌(26.2%)、金黄色葡萄球菌(22.8%)、大肠埃希菌(20.5%)、肺炎克雷伯菌(14.7%)和屎肠球菌(12.1%).耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)检出率分别为46.8%、35.2%;超广谱β内酰胺酶(ESBLs)阳性大肠埃希菌和肺炎克雷伯菌分别为23.9%、23.5%.葡萄球菌对青霉素、红霉素耐药率较高,屎肠球菌对青霉素耐药率相对较低;MRSA、MRCNS及ESBLs阳性大肠埃希菌和肺炎克雷伯菌多药耐药现象严重.结论 革兰阳性球菌为老年细菌性阴道炎主要致病菌,其中肠球菌耐药性较轻,革兰阴性杆菌检出率相对较低.

Distribution and drug resistance analysis of pathogenic bacteria in senile bacterial vaginitis

Objective To investigate the distribution and drug resistance of bacteria isolated from patients with senile bacterial vaginitis.Methods Detection results of isolation,culture,identification and susceptibility test for pathogenic bacteria in vaginal discharge specimens from patients with senile bacterial vaginitis during 2008-2010 were retrospectively analyzed.Results The major pathogenic bacteria were coagulase negative staphylococci(CNS) for 26.2%,Staphylococcus aureus for 22.8%,Escherichia coli for 20.5%,Klebsiella peneumoniae for 14.7%,Enterococcus species for 12.1%.The detection rate of MRSA and MRCNS were 46.8% and 35.2%,of ESBLs producing E.coli and K.pneumoniae were 23.9% and 23.5%.Staphylococcus were highly resistant to penicillin and erythrocin,and Enterococcus species were lowly resistant to penicillin.E.coli and K.pneumoniae producing ESBLs,MRSA and MRCNS were with obvious multiple drug-resistance.Conclusion Gram postive cocci might be the main pathogenic bacteria in senile bacterial vaginitis,in which Enterococcus species were with slight drug resistance.The detection rate of gram negative baclli was relatively low.