妊娠高血压综合征患者血液流变学指标的变化及分析

目的探讨妊娠高血压综合综合征患者血液流变学指标的变化及其临床意义。方法测定50例正常妊娠妇女及 85例妊高征患者(其中轻度妊高征27例,中度28例,重度30例)全血高低切粘度、血浆粘度、高低切还原粘度、红细胞压积、红细胞变形指数、红细胞电泳时间及纤维蛋白原、白蛋白和总蛋白含量等指标并进行比较。结果与正常妊娠组比较,妊高征组中上述血液流变学指标存在明显异常,差异有显著性(P<0．05-0．01);妊高征患者随病情的进展上述指标变化更趋明显,差异有显著性(P<0．05-0．01);而且上述指标在治疗后有明显改善,差异较治疗前亦有显著性(P<0．05-0．01)。结论妊高征患者血液流变性的特点表现为血液浓稠,粘滞性增高,红细胞变形能力降低,聚集性增强,血浆纤维蛋白原含量增加,白蛋白和总蛋白含量降低。为妊高征的诊断、治疗、疗效及预后判定提供了理论依据。

Analysis of Clinical Significance on Hemorheological Indexes in Patients with Pregnancy Induced Hypertension Syndrome

Objective To explore the hemorheology changes and its clinical significance of patients with pregnancy induced hypertension syndrome. Method Hemorheological indexes of 50 cases of normal late pregnancy women (NP group) and 85 cases of patients with pregnancy induced hypertension syndrome (PIH group) were detected. Results The hemorheological parameters in PIH group including blood viscosity,plasma viscosity,hematocrit, erythrocyte transmutative ability, and fibrinogen level were significantly higher than those of NP groups(P<0.05 -0.01);There is a positive correlation between the indexes and disease severity and after effective treatment the indexes were improved markedly in PIH group(P><0.05-0.01).Conclusion Hemorheological indexes may be helpful for PIH patients in dignosis,treatment,and so on.