肌萎缩侧索硬化60例临床分析

目的探讨肌萎缩侧索硬化(ALS)的临床特征,为进一步研究其病因、发病机理和治疗提供临床数据支持。方法记录60例确诊或拟诊的ALS病人临床资料,并对临床症状、体征及实验室检查数据进行统计学处理分析。结果平均发病年龄44.63±10.27岁,比西方国家发病年龄早。男女发病率之比是1.91。ALS症状进展从原发部位逐渐向水平或垂直方向波及临近部位。ALS患者血清IgG、IgM未见明显异常,而IgA、C3、C4明显升高。结论ALS是一种与年龄相关,好发于男性的疾病,疾病进展遵循一定规律。免疫系统参与了ALS的发病过程。

Clinical Analysis of 60 Cases of Amyotrophic Lateral Sclerosis

Objective: To study the clinical features of amyotrophic lateral sclerosis (ALS), and provide clinical data for further research in pathogenesis and therapy. Methods: We collected and reviewed prospectively the records of 60 cases of ALS. Clinical characteristics, symptoms, signs and data of laboratory examination on the patients were statistical analyzed. Results The mean age at oneset was 44.63±10.27 years , earlier than in the west country. The incidence of ALS increased with age until fifty years old. Sex ratio (male vs female) was 1.9:1.Symptoms and signs of ALS develop from the initial location to the near location vertically or horizontally. ALS patients had significantly higher mean values of serum IgA, C3, and C4 (P=0.0001). There were not significantly differences on the mean serum levels of IgG and IgM between patients and health control. Conclusion: ALS is an age-related, male predominant disease. The development of ALS follows some patterns. Immune system involves in human sporadic ALS.