正常高值血压人群血浆硫化氢水平与其高血压发生的关系

目的 研究正常高值血压人群血浆硫化氢（H2S）水平与其高血压发生的相关性。方法：回顾性分析1056例参加健康查体的正常高值血压者，去蛋白法检测血浆HS2含量；随访24个月后，按是否进展为高血压分为高血压组（226例）和无高血压组（830例），比较两组间血浆H2S水平差异；四分位法分析HzS含量与高血压发生率的关系；Logistic回归分析法研究H2S水平是否为高血压发生的危险因素。结果：高血压组血浆H2S含量明显低于无高血压组（32．54±3．61）umol／L比（50．62±3．84）umol／L，P〈0．01]；随H2S含量逐渐降低（〈60．72umol／L，〈51．84umol／L，〈42．97umol／L，〈34．09umol／L），高血压发生率逐渐升高（13．3％，15．0％，27．8％，35．8％，P〈0．01）；Logistic回归分析显示血浆H2S含量是导致高血压发生的危险因素（OR=2．821，P〈0．001）。结论：血浆硫化氢含量降低，可能是促进正常高值血压者向高血压进展的危险因素。

Correlation between plasma level of hydrogen sulfide and incidence of hypertension in people with high normal blood pressure

Objective:To investigate correlation between plasma level of hydrogen sulfide(H2S) and incidence of hypertension in people with high normal blood pressure.Methods:Clinical data of 1 056 subjects with high normal blood pressure undergoing health examination were retrospectively analyzed.Deproteinization method was used to measure plasma H2S concentration.After 24-month follow up,according to develop into hypertension or not,subjects were divided into hypertension group(n=226) and no-hypertension group(n=830).Plasma H2S level was compared between the two groups.Quartile method was used to analyze relation between H2S concentration and incidence rate of hypertension;Logistic regression analysis was used to study whether H2S level was a risk factor for incidence of hypertension.Results:Plasma H2S concentration of hypertension group was significantly lower than that of no-hypertension group (32.54±3.61) μmol/ L vs.(50.62±3.84) μmol/ L,P<0.01];the lower H2S concentration was(<60.72μmol/ L,<51.84μmol/ L,<42.97μmol/ L,<34.09μmol/ L),the higher incidence rate of hypertension was(13.3%,15.0%,27.8%,35.8%,P<0.01);Logistic regression analysis indicated that plasma H2S concentration was a risk factor of hypertension(OR=2.821,P<0.001).Conclusion:Decrease of plasma concentration of hydrogen sulfide may be a risk factor makeing people with high normal blood pressure develop into hypertension patient.