从过咸伤肾探讨糖尿病肾脏损害的发病机制

糖尿病肾脏损害为糖尿病常见的并发症,中医脏象理论有"咸入肾""过咸伤肾"等理论。糖尿病及糖尿病肾脏损害患者均被限制食盐的摄入量,高盐的摄入对糖尿病肾脏损害的影响和作用机制具有复杂性和多样性,可以引起微量白蛋白尿的发生与发展、损害肾功能、升高血压,加重糖尿病肾脏损害。高盐摄入主要通过激活肾素-血管紧张素-醛固酮系统、引起糖脂代谢紊乱及上皮钠离子通道等参与糖尿病肾脏损害的发生与发展。

Discussion about Diabetic Kidney Disease Injury Based on the Theory of Excessive Salt Hurting Kidney

Diabetic kidney disease injury is a common complication of diabetes.The visceral manifestation theory of Chinese medicine has the theory of"salt into the kidney"and"excessive salt hurting kidney".Patients with diabetes and diabetic kidney injury are all restricted by the intake of salt.The effects and mechanisms of high salt intake on diabetic kidney injury are complex and diverse,which can cause the occurrence and development of microalbuminuria,damage kidney function,increase hypertension and aggravate kidney injury in patients with diabetic kidney diseas.High salt intake mainly participates in the occurrence and development of diabetic kidney injury by activating the rennin-angiotensin-aldosterone system,causing glucose and lipid metabolism disorders and epithelial sodium channels.