广州市280例6～12岁正常儿童肺功能测定值及其意义

目的：我国健康学龄儿童的肺功能正常值的参考值是在上世纪80年代末至90年代初期建立的,随着国人生活质量和生命质量的提高,学龄儿童尤其是小学生的肺功能的变化如何尚未清楚,且不同地区的学龄儿童,其肺功能变化也可能不一样,因此有必要建立新的本地区学龄儿童的肺功能正常值。该文目的是建立广州市6～12岁小学儿童肺功能正常值。方法：应用医疗国际股份有限公司产的SpiroliteTM303型肺功能仪测定广州市在校健康的6～12岁儿童的肺功能值,测定的指标有14个,取最能反映肺功能的4个参数作为测定指标,即用力肺活量(FVC)、第1秒时间用力呼出气体容量(FEV1)、最高呼气流速(PEF)和最大呼气中段流速(FEF25%75%)。1岁为一个年龄组,共7组,每年龄组40例,总计280例,男女不限,测量其体重、身高,每个测试者测3次,取最好的一次结果记录打印。结果：280例中男139例,平均身高135.05±13.42cm,平均体重32.93±7.39kg,FVC3.40±0.96L,FEV13.03±0.87L,PEF6.42±2.32L,FEF25%75%3.58±1.32L;女141例,平均身高135.66±12.62cm,平均体重33.06±6.85kg,FVC3.22±1.07L,FEV12.88±0.93L,PEF5.84±2.17L,FEF25%75%3.59±1.28L。结论：儿童肺功能指标受年龄、性别、身高和体重的影响,不同的指标受影响的因素不全相同,FVC,FEV1,PEF和FEF25%75%均与年龄、身高成正相关,单因素分析时FVC,FEV1,PEF和FEF25%75%均与体重正相关,PEF与性别正相关,多元回归分析时FVC,FEV1,PEF和FEF25%75%均与体重无关,FVC,FEV1,PEF与性别相关。年龄和身高是影响儿童肺功能测定指标的最重要的因素。

Mean values of pulmonary function parameters from 280 healthy schoolchildren aged 6 to 12 years in Guangzhou

OBJECTIVE: The reference values of pulmonary function for healthy schoolchildren were established between late 1980's and early 1990's. Whether the improvement of life quality influences the pulmonary function values of schoolchildren remains unknown. Moreover, the pulmonary function values of children from different regions might be different. This study aimed to investigate the mean values of pulmonary function parameters in healthy children aged 6 to 12 years in Guangzhou. METHODS: Spirolite TM 303 pulmonary function test spirometer was used to measure the mean values of pulmonary function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV_1), peak expiratory flow (PEF) and forced expiratory flow during middle half of FVC (FEF_ 25%-75%), in 280 healthy schoolchildren between 6 and 12 years old of both sexes from a primary school of Guangzhou. The subjects selected by random sampling were assigned into 7 groups according age (n=40 each), 1 year as a group separation. Their weights and heights were measured. RESULTS: In 139 boys the mean weight and height were 32.93±7.39 kg and 135.05±13.42 cm, respectively. The mean FVC was 3.40±0.96 L, FEV_1 3.03±0.87 L, PEF 6.42±2.32 L and FEF_ 25%-75% 3.58±1.32 L . In 141 girls the mean weight and height were 33.06±6.85 kg and 135.66±12.62 cm, respectively. The mean FVC was 3.22±1.07 L, FEV_1 2.88±0.93 L, PEF 5.84±2.17 L and FEF_ 25%-75% 3.59±1.28 L. Monovariable analysis showed that all the four parameters were positively related to height and weight but multivariable regression analysis did not demonstrate a correlation between the four parameters and weight. Monovariable analysis showed that PEF was related to gender but FVC, FEV_1 and FEF_ 25%-75%, were irrelevant. However multivariable regression analysis showed that FVC and FEV_1 were also correlated to gender. Either the monovariable analysis or the multivariable regression analysis demonstrated that all the four parameters were positively related to age. CONCLUSIONS: This study reported a reference range of the pulmonary function values for healthy schoolchildren aged 6 to 12 years in Guangzhou. Age, height, weight and gender may be related to the pulmonary function values. Among them, age and height are more important impact factors.