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| 中药复光颗粒对家兔视神经夹伤后Bcl-2和Bax表达的影响 | |
| 引用本文： | 朱劲,江文,黄玲,张晓,周华祥,张燕. 中药复光颗粒对家兔视神经夹伤后Bcl-2和Bax表达的影响[J]. 国际眼科杂志, 2011, 11(5): 792-794. DOI: 10.3969/j.issn.1672-5123.2011.05.013 |
| 作者姓名： | 朱劲 江文 黄玲 张晓 周华祥 张燕 |
| 作者单位： | 1. 核工业416医院眼科,中国四川省成都市,610041 2. 成都中医药大学附属医院眼科,中国四川省成都市,610041 3. 四川省妇幼保健院,中国四川省成都市,610041 |
| 摘 要： | 目的:观察复光颗粒对家兔受损视神经的保护作用。方法:采用视神经夹伤方法,建立家兔外伤性视神经病变(traumatic optic neuropathy,TON)模型,通过测定凋亡相关基因Bcl-2和Bax的表达,观察复光颗粒对受损视神经的影响。结果:视神经夹伤后,凋亡相关基因Bcl-2和Bax的表达及Bcl-2/Bax值在复光颗粒组间(低、高剂量组)比较无显著差异性(P>0.05)。而复光颗粒各组与模型对照组间均有显著差异(P<0.05),复光颗粒各组较模型组Bcl-2表达增加,Bax表达减少。结论:在本实验条件下,复光颗粒具有上调抗凋亡基因Bcl-2和下调促凋亡基因Bax表达的作用,可减轻视神经损伤的作用。 |
| 关 键 词： | 视神经夹伤 家兔 Bax Bcl-2 凋亡基因 外伤性视神经病变 |
Effect of fuguang pellet on Bcl-2 and Bax expression after optic nerve crush in rabbits |
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| Jin Zhu,Wen Jiang,Ling Huang,Xiao Zhang,Hua-Xiang Zhou and Yan Zhang. Effect of fuguang pellet on Bcl-2 and Bax expression after optic nerve crush in rabbits[J]. International Eye Science, 2011, 11(5): 792-794. DOI: 10.3969/j.issn.1672-5123.2011.05.013 | |
| Authors: | Jin Zhu Wen Jiang Ling Huang Xiao Zhang Hua-Xiang Zhou Yan Zhang |
| Affiliation: | Jin Zhu1,Wen Jiang1,Ling Huang1,Xiao Zhang1,Hua-Xiang Zhou2,Yan Zhang31Department of Ophthalmology,416 Hospital of Nuclear Industry,Chengdu 610041,Sichuan Province,China,2Department of Ophthalmology,the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,3Maternal and Child Health Hospital of Sichuan Province |
| Abstract: | ·AIM:To observe the protective effect of fuguang pellet on optic nerve through the research of expression of apoptosis-related genes(Bcl-2,Bax)in the rabbits after crushing the optic nerve with microforceps.·METHODS:By the method of crushing rabbit optic nerve,the models of traumatic optic neuropathy(TON)were set up.By determination of the expression of apoptosis-related genes(Bcl-2,Bax)in the rabbits’ optic nerve,the influence of the fuguang pellet on injured optic nerve was observed.·RESULTS:After the rabbits’ optic nerve was crushed,there were significant differences in the expression of apoptosis-related genes(Bcl-2,Bax)between model group and the group of the fuguang pellet(P<0.05).There were no significant differences between the group of high-dosage group and low-dosage group of the fuguang pellet.·CONCLUSION:Fuguang pellet can decrease damages of optic nerve by increasing Bcl-2 gene expression and restraining Bax gene expression in this experiment.· |
| Keywords: | Bax Bcl-2 |
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