豚鼠形觉剥夺早期生物学参数的动态变化研究

目的:研究幼年豚鼠形觉剥夺早期生物学参数变化,得出其形觉剥夺早期过程中屈光动态的变化规律。方法:将20只豚鼠(出生后大约3wk)随机分成2组:MDF组(单眼面罩形觉剥夺组,n=10)和正常对照组(n=10)。面罩组和正常对照组的动物在形觉剥夺开始前和开始后2,4,6,10和14d进行了双眼的生物学测量(屈光力、眼轴各部分长度及视网膜、脉络膜厚度)。结果:MDF组实验眼脉络膜厚度在第10,14d较对侧眼有显著性差异(P<0.05),但较正常对照眼均无显著性差异。结论:豚鼠形觉剥夺早期视网膜并不发生明显的厚度和病理改变,而脉络膜厚度有缩短的趋势。

Dynamic changes in biometric parameters of early deprivation in guinea pigs

AIM:To observe the early dynamic changes of biometric parameters in guinea pigs model. METHODS: Twenty guinea pigs (age of 3 weeks) were randomly assigned to two groups: monocularly deprived facemask (MDF) group (n=10) and normal control group (n=10). All animals underwent biometric measurement (refraction, axial length and OCT) prior to the experiment. All animals in the MDF group underwent biometric measurement at each of the 5 time points (2, 4, 6, 10 and 14 days of form deprivation). RESULTS: In MDF group, choroidal thickness in experimental eye had become thinner than contralateral eye at 10, 14 days, but there were no significant differences between experimental eye and normal control eye.CONCLUSION: In early deprivation of guinea pigs’eyes, there is no significantly pathological and retinal thickness change. However, there is a trend towards shorter choroidal thickness.