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| 江苏省首例人感染高致病性禽流感病例的确认及其病原的基因特征研究 | |
| 引用本文： | 潘浩,祖荣强,陆小军,朱凤才,李亮,史智阳,鲍昌俊,李显,邓斐,汪华.江苏省首例人感染高致病性禽流感病例的确认及其病原的基因特征研究[J].现代预防医学,2010,37(7). |
| 作者姓名： | 潘浩 祖荣强 陆小军 朱凤才 李亮 史智阳 鲍昌俊 李显 邓斐 汪华 |
| 作者单位： | 1. 江苏省疾病预防控制中心,南京,210009;上海市疾病预防控制中心 2. 江苏省疾病预防控制中心,南京,210009 3. 南京市疾病预防控制中心 |
| 摘 要： | 目的]确认2007年12月江苏省首例人感染高致病性禽流感病例,探究病例的临床变化规律及其病原的基因特征。方法]通过知情人访谈和查阅病志方式开展流行病学调查,病例密切接触者进行医学观察。采集病例气管吸取物呼吸道标本,运用荧光定量RT-PCR法进行H5N1基因检测,并开展病毒分离,分析血凝素(HA)基因特征。结果]病例无明确禽类接触和暴露史,69名密切接触者患者父亲发病。病例病后d5后即出现"白肺",病后d8死亡,白细胞和血小板进行性下降。下呼吸道标本H5N1病毒HA和NA基因均为阳性,病原培养物经鉴定为H5亚型禽流感病毒。该分离株HA基因同源性分析显示接近我国浙江、安徽等地分离株(99.0%,98.9%)。系统发生树分析为CladeⅡ系的2.3.4基因亚群,病毒HA1和HA2连接肽及细胞受体结合位点分析表明该分离株仍为禽源特性。结论]该病例为江苏省首例人感染高致病性禽流感(H5N1)病例,无明确的禽类暴露史。分离株为2.3.4基因亚群,基因特征仍为禽源特性。 |
| 关 键 词： | 高致病性禽流感 基因特征 |
DIAGNOSIS AND MOLECULAR CHARACTERISTICS STUDY ON THE FIRST CASE OF HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS (H5N1) IN JIANGSU |
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| PAN Hao,ZU Rongqiang,LU Xiao-jun,et al..DIAGNOSIS AND MOLECULAR CHARACTERISTICS STUDY ON THE FIRST CASE OF HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS (H5N1) IN JIANGSU[J].Modern Preventive Medicine,2010,37(7). | |
| Authors: | PAN Hao ZU Rongqiang LU Xiao-jun |
| Institution: | PAN Hao,ZU Rongqiang,LU Xiao-jun,et al.(Jiangsu Provincial Center for Disease Control , Prevention,Nanjing 210009,China) |
| Abstract: | Objective] To confirm the first H5N1 avian influenza infected case in November 2007 in Nanjing,and describe clinical manifestations of the case and analyze the genetic characteristics of virus isolated from the case.Methods] Information on epidemiology and clinical manifestations of the case were collected by key informant interview and referring to related medical records.The poultry exposure of the case and the timeline of the illness were reproduced.The tracheal aspirate from the case was collected and... |
| Keywords: | H5N1 |
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