| 烟叶中1个新的开环西松烷二萜类化合物 |
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| 引用本文： | 郑庆霞,马国需,翟妞,刘萍萍,陈霞,陈千思,金立锋,周会娜.烟叶中1个新的开环西松烷二萜类化合物[J].中草药,2015,46(14):2040-2044. |
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| 作者姓名： | 郑庆霞 马国需 翟妞 刘萍萍 陈霞 陈千思 金立锋 周会娜 |
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| 作者单位： | 中国烟草总公司郑州烟草研究院, 河南 郑州 450000;中国医学科学院 北京协和医学院药用植物研究所, 中草药物质基础与资源利用教育部重点实验室, 北京 100193;中国烟草总公司郑州烟草研究院, 河南 郑州 450000;中国烟草总公司郑州烟草研究院, 河南 郑州 450000;中国烟草总公司郑州烟草研究院, 河南 郑州 450000;中国烟草总公司郑州烟草研究院, 河南 郑州 450000;中国烟草总公司郑州烟草研究院, 河南 郑州 450000;中国烟草总公司郑州烟草研究院, 河南 郑州 450000 |
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| 基金项目： | 烟草基因组重大专项项目:典型香型烟草品质形成的代谢特征研究(902014AA0530) |
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| 摘 要： | 目的研究烟草Nicotiana tabacum叶中的西松烷类化学成分。方法采用硅胶柱色谱及高效液相色谱等方法进行分离纯化,根据理化性质及波谱数据对化合物的结构进行鉴定。结果从烟叶95%乙醇提取物中分离得到5个西松烷二萜类成分,分别鉴定为(1S,2E,4R,6R,7E)-4,6,11-trihydroxy-1-isopropyl-4,8-dimethylpentadeca-2,7-dien-12-one(1)、(1S,2E,4R,6R,7E,11E)-2,7,11-cembradiene-4,6-diol(2)、(1S,2E,4S,6R,7E,11E)-2,7,11-cembradiene-4,6-diol(3)、(1S,2E,4R,6R,7E,11S)-2,7,12(20)-cembratriene-4,6,11-triol(4)、(1S,2E,4S,6R,7E,11S)-2,7,12(20)-cembratriene-4,6,11-triol(5)。结论化合物1为新化合物,命名为烟叶二萜A。
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| 关 键 词： | 烟草属 烟叶 西松烷二萜 开环 烟叶二萜A |
| 收稿时间： | 4/3/2015 12:00:00 AM |
A new chain-like cembranoid diterpene from leaves of Nicotiana tabacum |
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| ZHENG Qing-xi,MA Guo-xu,ZHAI Niu,LIU Ping-ping,CHEN Xi,CHEN Qian-si,JIN Li-feng and ZHOU Hui-na.A new chain-like cembranoid diterpene from leaves of Nicotiana tabacum[J].Chinese Traditional and Herbal Drugs,2015,46(14):2040-2044. |
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| Authors: | ZHENG Qing-xi MA Guo-xu ZHAI Niu LIU Ping-ping CHEN Xi CHEN Qian-si JIN Li-feng and ZHOU Hui-na |
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| Institution: | Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China;Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China;Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China;Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China;Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China;Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China;Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450000, China |
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| Abstract: | Objective To study the cembranoid diterpenes from the leaves of Nicotiana tabacum. Methods The cembranoid diterpenes were isolated and purified by silica gel and preparative HPLC, and their structures were elucidated on the basis of their physicochemistry properties and spectral data. Results Five cembranoid diterpenes were obtained from the ethanol extract of the leaves of N. tabacum and identified as (1S,2E,4R,6R,7E)-4,6,11-trihydroxy-1-isopropyl-4,8-dimethylpentadeca-2,7-dien-12-one (1), (1S,2E,4R,6R,7E,11E)-2,7,11-cembradiene-4,6-diol (2), (1S,2E,4S,6R,7E,11E)-2,7,11-cembradiene-4,6-diol (3), (1S,2E,4R,6R,7E, 11S)-2,7,12 (20)-cembratriene-4,6,11-triol (4), and (1S,2E,4S,6R,7E,11S)-2,7,12(20)-cembratriene-4,6,11-triol (5). Conclusion Compound 1 is a new chain-like cembranoid diterpene named nicotiaditerpene A. |
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| Keywords: | Nicotiana L Nicotiana tabacum L cembranoid diterpenes chain-like diterpene nicotiaditerpene A |
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