| 氯氰菊酯对大鼠肝脏磷酸化酶a、Ca~（2＋）－ATP酶活力的影响 |
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| 引用本文： | 夹访贤,张秀莲,于丽华. 氯氰菊酯对大鼠肝脏磷酸化酶a、Ca~（2＋）－ATP酶活力的影响[J]. 中国公共卫生学报, 1995, 0(2) |
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| 作者姓名： | 夹访贤 张秀莲 于丽华 |
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| 作者单位： | 山东医科大学 |
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| 摘 要： | 采用整体和离体相结合方法、观察了氯氰菊酯对大鼠肝脏磷酸化酶ａ、Ｃａ２＋－ＡＴＰ酶活力的影响。整体实验表明．氯氰菊酯染毒后可使大鼠肝脏磷酸化酶ａ明显升高．Ｃａ２＋－ＡＴＰ酶含量明显下降，与对照组相比有显著性差异（Ｐ＜０．０５或Ｐ＜０．０１）．且存在明显的剂量－效应关系、而离体实验表明．氯氰菊酯也可引起大鼠肝线粒体、微粒体Ｃａ２＋－ＡＴＰ酶显著下降．也存在明显的剂量－效应关系．
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| 关 键 词： | 氯氰菊酯；磷酸化酶a；Ca~（2＋）－ATP酶；线粒体；微粒体 |
Effect of Cypermethrin on Activity of Phosphorylase A and Ca-ATPase of Rat Liver |
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| Jia Fangxian,et al.. Effect of Cypermethrin on Activity of Phosphorylase A and Ca-ATPase of Rat Liver[J]. , 1995, 0(2) |
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| Authors: | Jia Fangxian et al. |
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| Affiliation: | Dept of Nuclear Medicine.Shandong Medical University Jinan 250012 |
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| Abstract: | In this paper we observed the effect of Cypermethrin on the activity of phosphorylase A and Ca-ATPase of rat liver in vivo and vitro. The result indicated that in vivo Cypermethrin could inhibited the activity of Ca-ATPase .and it could also increased the activity of phosphorylase (P<0.05 or P< 0. 01 )and dose-effect relation was existed.It also indicated that in vitro Cypermethirn could inhibited the activity of Ca-ATPase of rat liver mitochodria and microsomeand dose-effect relation was existed. |
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| Keywords: | Cypermethin Phosphorylase A Ca-AT-Pase Mitochondria Microsome |
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