| 一氧化氮和脂质过氧化物在门脉高压性胃病患者中的变化 |
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| 引用本文： | 刘进进,李健,屠柏强,王秀玲. 一氧化氮和脂质过氧化物在门脉高压性胃病患者中的变化[J]. 胃肠病学, 2003, 8(5): 292-293 |
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| 作者姓名： | 刘进进 李健 屠柏强 王秀玲 |
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| 作者单位： | 上海第二医科大学附属瑞金医院卢湾分院消化内科,200020 |
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| 摘 要： | 背景:胃黏膜糜烂是肝硬化患者发生上消化道出血的重要原因之一。目的:探讨血清和胃黏膜内一氧化氮(NO)和脂质过氧化物(LPO)的变化在门脉高压性胃病(PHG)发病中的作用。方法:将43例PHG患者随机分为两组,20例患者采血清,23例患者取胃黏膜,分别采用硝酸还原法和硫代巴比妥酸(TBA)比色法测定NO和LPO含量。结果:PHG患者血清和胃黏膜内的NO和LPO含量均显著高于对照组(P<0.001)。结论:PHG患者血清和胃黏膜内NO和LPO含量增高可能参与了PHG的发病机制。
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| 关 键 词： | 一氧化氮 脂质过氧化物 门脉高压性胃病 胃黏膜糜烂 肝硬化 |
| 修稿时间： | 2003-05-21 |
Changes of Nitric Oxide and Lipid Peroxide in Patients with Portal Hypertensive Gastropathy |
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| LIU Jinjin,LI Jian,TU Baiqiang,WANG Xiuling. Changes of Nitric Oxide and Lipid Peroxide in Patients with Portal Hypertensive Gastropathy[J]. Chinese Journal of Gastroenterology, 2003, 8(5): 292-293 |
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| Authors: | LIU Jinjin LI Jian TU Baiqiang WANG Xiuling |
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| Abstract: | Background: Gastric mucosal erosions are one of the important factors causing upper gastrointestinal hemorrhage in patients with cirrhosis. Aims: To investigate the role of the changes of serum and gastric mucosal nitric oxide (NO) and lipid peroxide (LPO) in the occurrence of portal hypertensive gastropathy (PHG). Methods: Forty-three PHG patients were randomly divided into two groups. In 20 of them, serum concentrations of NO and LPO were detected by nitric acid deoxidization method and thiobarbiturate (TEA) chromatography, respectively. In the other 23 patients, gastric mucosal concentrations of NO and LPO were measured. Results: The serum and gastric mucosal concentrations of NO and LPO in PHG patients were significantly higher than those in the controls (P< 0.001). Conclusions: Increased concentrations of NO and LPO in serum and gastric mucosa may be involved in the patho-genesis of PHG. |
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| Keywords: | Portal Hypertensive Gastropathy Nitric Oxide Lipid Peroxides |
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