失血再灌注胃体部粘膜损伤及丹参提取物F与甲氰咪胍防？…

目的：观察失血再灌注胃体部粘膜损伤及丹参提取物Ｆ与甲氰咪胍抗胃粘膜损伤的作用。方法：复制大鼠失血性休克再灌注损伤模型。实验分生理盐水（ＮＳ）组，丹参提取物Ｆ（ＤＳＥＦ）组及甲氰咪胍（ＣＩ）组，结果：（１）ＤＳＥＦ组及ＣＩ组的胃体部粘膜损伤指数及重度损伤明显低于ＮＳ组，但（ｔｐ－ＰＧＦ１α）及６－ｋｅｔｏ－ＰＡＦ１α／血栓素差异。（２）ＤＳＥＦ组的前列腺素Ｅ２（ＰＧＥ２），６－酮－前列腺素Ｆ１α（６

Mucosal Injury of Gastric Corpus by Hemorrhage Reperfusion and Comparison between Preventing and Therapeutic Effect of Salvia Extract F and Cimetidine

OBJECTIVE: To observe the mucosal injury of gastric corpus caused by hemorrhage reperfusion and to compare the anti-mucous injure effect between Salvia extract (SE) and cimetidine (CI) on it. METHODS: Model of hemorrhagic shock reperfusion injury was produced by Itoh method. Wistar rats used in this experiment were randomly divided into three groups, the normal saline (NS) group, the SE group and the CI group. RESULTS: (1) As compared with those in the NS control group, the index and depth of gastric mucosal lesion in the SE group and the CI group decreased significantly (P < 0.01), but the difference between the latter two was insignificant (P > 0.05). (2) Compared with those in the NS group and the CI group, the levels of PGE2, 6-keto-PGF1 alpha and 6-keto-PGF1 alpha/TXB2 raised and TXB2 lowered obviously in the SE group, while no significant difference was shown between those in the NS group and the CI group. (3) The intracellular calcium content in the SE group and the CI group was markedly higher than that in the NS group (P < 0.01), but there was insignificant difference between the SE and the CI group (P > 0.05). CONCLUSIONS: Both SE and CI could inhibit the gastric mucosal reperfusion injury, but with different mechanisms. SE could not only enhance the protective factors of gastric mucosa, but also abate the injury factors of it, while CI has the latter only.