Phospholipase A2 inhibitors (βPLIs) are encoded in the venom glands of Lachesis muta (Crotalinae, Viperidae) snakes |
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| Authors: | Rebeca Mascarenhas LimaMaria Iná cia Estevã o-Costa,Iná cio L.M. Junqueira-de-AzevedoPaulo Lee Ho,Marcelo Ribeiro Vasconcelos DinizConsuelo Latorre Fortes-Dias |
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| Affiliation: | a Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Rua Conde Pereira Carneiro 80, CEP 30510-010, Belo Horizonte, MG, Brazil
b Instituto Butantan, Av. Vital Brazil, 1500, CEP 05503-900, São Paulo, SP, Brazil |
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| Abstract: | Phospholipase A2 inhibitors (PLIs) are glycoproteins secreted by snake liver into the circulating blood aiming the self-protection against toxic venom phospholipases A2. In the present study, we describe the first complete nucleotide sequence of a βPLI from venom glands of a New World snake, Lachesis muta. The deduced primary structure was compared to other known βPLIs and recent literature findings of other possible roles of PLIs in snakes are discussed. |
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| Keywords: | Phospholipase A2 inhibitor PLI Phospholipase A2 PLA2 Lachesis Venom gland |
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