正交试验法优选右旋糖酐40葡萄糖注射液澄明度的工艺

目的：应用正交试验法优选右旋糖酐４０葡萄糖注射液澄明度的工艺。方法；选择活性髅用量，中间品ｐＨ值与砂棒回流时间等三因素，每个因素取２个水平，按Ｌ８（２＾７）正交安排实验，用２个指标评定工艺的优劣。结果；采用活性炭用量为３．０％，中间品ｐＨ值为４．５，砂棒回流时间４５ｍｉｎ的工艺条件最佳。

Optimum technigues raising clarity of dextran 40 glucose injection by orthogonal test

OBJECTIVE:To seek the optimum techniques raise dextran 40 glucose injection clarity by orthogonal test. METHODS:To arrange the test according to the L8 (27 ) orthogonal table, we selected three factors as dosage of active carbon,pH of intermediate product,time of reflux passing diatomaceous filter,each of which took two levels,to assess the technigues in the two indexes.RESULTS:The optimum technique was that the dosage of active carbon was 3.0% ,pH of intermediate product was 4.5,time of reflux passing diatomaceous filter was 45 min.CONCLUSION:It's feasible to seek the optmum technigues raising clarity of dextran 40 glucose injection by orthogonal test