inflammatory reaction and laboratory tests: granulocyte elastase |
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| Authors: | I Sakurabayashi K Shimanuki A Shinpo S Ishii |
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| Institution: | Department of Clinical Laboratory, Omiya Medical Center, Jichi Medical School. |
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| Abstract: | The role in the so called inflammatory response of the polymorphonuclear granulocyte elastase (PMN elastase, EC 3.4.21.37) has been well established. Elastase, a neutral protease stored in the lysosomes of neutrophils and monocytes, is extracellularly released during the process of phagocytosis, and bound to alpha 1-proteinase inhibitor (E-alpha 1-PI complex). This complex can be quantified by an immunoassay. PMN elastase has been shown to be a sensitive and specific marker for the early diagnosis of inflammation and prediction of inflammatory complications. |
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