妇科恶性肿瘤患者术后血液血栓前状态的检测

目的：探讨妇科恶性肿瘤患者血栓前状态生物指标的变化。方法：检测38例妇科恶性肿瘤患者手术前后及20例正常非孕妇女的血管性血友病因子（vWF)、血小板α－颗粒膜蛋白（GMP－140）、抗凝血酶（AT－Ⅲ）、蛋白C依赖的活化部分凝血酶原时间（PCAT）、纤溶酶原（PLG）、纤溶酶原激活物抑制物（PAI）、D－二聚体和组织纤溶酶原激活物（t-PA)等指标。结果：妇科恶性肿瘤患者术前vWF含量、GMP－140、AT－Ⅲ、PLG、PAI、D－二聚体均比对照组高（P＜0．01），而术后升高更明显；PCAT手术前、后均明显低于正常非孕妇女；而组织纤溶酶原激活物（t-PA) 则无显著性改变（P＞0．05）。结论：提示妇科恶性肿瘤患者术前血液呈血栓前状态，术后呈更明显的血栓前状态。

Assessment of variables relative to prethrombotic state after operation in patients with gynecological malignancies]

OBJECTIVE: To study the changes in the variables in patients with gynecological malignancies after operation. METHOD: Platelet alphagranule membrane protein (GMP-140), von Willebrand Factor (vWF), antithrombin III activity (AT-III), protein C-dependent partial thromboplastin activation time, plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI), D-Dimer were examined in 20 normal non-pregnant women and 38 patients after operation with gynecological malignancies. RESULTS: vWF, GMP-140, PLG, D-Dimer, and PAI of patients with malignancies before operation were obviously higher than those of the healthy women (P<0.01). After operation the parameters were obviously elevated in the patients (P<0.01). AT-III and partial thromboplastin activation time were significantly reduced in comparison with the healthy subjects (P<0.01). t-PA showed no significant difference between the groups (P>0.05). CONCLUSIONS: Obvious prethrombotic state characterizes the patients with gynecological malignancies after operation.