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莫西沙星治疗泌尿生殖系支原体感染的对比研究
引用本文:张万帆,谢守霞,杨吉乡,李江林.莫西沙星治疗泌尿生殖系支原体感染的对比研究[J].中华医院感染学杂志,2004,14(5):567-569.
作者姓名:张万帆  谢守霞  杨吉乡  李江林
作者单位:暨南大学医学院附属第二医院深圳市人民医院,广东,深圳,518020
摘    要:目的观察莫西沙星治疗泌尿生殖系支原体感染的临床疗效、安全性并与司帕沙星、左氧氟沙星进行比较. 方法 129例支原体感染的患者随机分为3组:莫西沙星组口服莫西沙星400 mg,qd,疗程为14 d;司帕沙星组口服司帕沙星200 mg,qd,疗程为14 d;左氧氟沙星组口服左氧氟沙星200 mg,bid,疗程为14 d;采用法国生物梅里埃IST试剂盒对患者标本进行支原体培养,并观察临床疗效及不良反应. 结果 3组患者临床痊愈率和总有效率分别是74.4%、65.1%、53.5%和95.3%、90.7%、69.8%;病原体清除率分别为90.7%、88.4%、67.4%.莫西沙星组、司帕沙星组与左氧氟沙星组相比差异有显著性意义,未发生严重的不良反应. 结论莫西沙星是一种治疗泌尿生殖系支原体感染高效、安全、服用方便的抗菌药物.

关 键 词:莫西沙星  司帕沙星  左氧氟沙星  泌尿生殖系  支原体感染
文章编号:1005-4529(2004)05-0567-03
修稿时间:2003年10月18

Moxifloxacin in Treatment of Mycoplasma Infection in Urinary and Reproductive System:Randomized Controlled Study
ZHANG Wan-fan,XIE Shou-xia,YANG Ji-xiang,LI Jiang-lin.Moxifloxacin in Treatment of Mycoplasma Infection in Urinary and Reproductive System:Randomized Controlled Study[J].Chinese Journal of Nosocomiology,2004,14(5):567-569.
Authors:ZHANG Wan-fan  XIE Shou-xia  YANG Ji-xiang  LI Jiang-lin
Abstract:OBJECTIVE To observe the clinical efficacy and safety of moxifloxacin in treatment of mycoplasma infection in urinary and reproductive system and to compare moxifloxacin with sparfloxacin or levofloxacin. METHODS A total of 129 cases with mycoplasma infection in urinary and reproductive system were randomly assigned to three groups: moxifloxacin group was treated with moxifloxacin 400 mg qd for 14 d;sparfloxacin group was treated with sparfloxacin 200 mg qd for 14 d and levofloxacin group was treated with levofloxacin 200 mg bid for 14 d. Mycoplasma cultures with the use of the France Bio-Merieux IST kit were conducted in 129 cases. RESULTS The cure rates and overall effective rates of three groups were 74.4%,65.1%,53.5% and 95.3%, 90.7%, 69.8%,respectively. The pathogen clearance rates were 90.7%,88.4%,67.4%,respectively. There were significant difference between moxifloxacin and levofloxacin groups or sparfloxacin and levofloxacin groups;No severe adverse reaction occurred in three groups. CONCLUSIONS Moxifloxacin is a very effective antibiotic in treating mycoplasma infection in urinary and reproductive system with a few adverse reaction and convenient administration.
Keywords:Moxifloxacin  Sparfloxacin  Levofloxacin  Urinary and reproductive system  Mycoplasma infection
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