| 异烟腙类衍生物TJU103对人T细胞增殖和细胞因子分泌的影响 |
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| 引用本文： | 张立成,郭坤元,王燕. 异烟腙类衍生物TJU103对人T细胞增殖和细胞因子分泌的影响[J]. 中国免疫学杂志, 2004, 20(3): 178-179 |
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| 作者姓名： | 张立成 郭坤元 王燕 |
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| 作者单位： | 1. 第一军医大学珠江医院,广州,510282
2. 山东药材技工学校,泰安,271000 |
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| 基金项目： | 全军医学科学技术研究“十五”计划重点课题 (0 1Z0 2 5 0 ) |
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| 摘 要： | 目的 :探讨异烟腙类衍生物TJU10 3体外对同种异体抗原刺激的T淋巴细胞增殖和细胞因子分泌的影响。方法 :采用MTT法和酶联免疫吸附实验 (ELISA)分别观察了TJU10 3对T细胞增殖和分泌细胞因子的影响。结果 :TJU10 3在 5 0mg/L浓度时 ,能够明显降低HLA半相合供、受者间混合淋巴细胞反应 (MLR)以及肿瘤坏死因子α(TNF α)和γ干扰素 (IFN γ)等细胞因子的分泌 (P <0 0 1)。结论 :TJU10 3能够特异性地与CD4 T细胞结合 ,降低CD4 T细胞的增殖和细胞因子分泌。
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| 关 键 词： | TJU103 T淋巴细胞 增殖 细胞因子 |
| 文章编号： | 1000-484X(2004)03-0178-02 |
Effects of TJU103 on T lymphocytes proliferation and cytokine production |
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| ZHANG Li-Cheng,GUO Kun-Yuan,WANG Yan. Effects of TJU103 on T lymphocytes proliferation and cytokine production[J]. Chinese Journal of Immunology, 2004, 20(3): 178-179 |
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| Authors: | ZHANG Li-Cheng GUO Kun-Yuan WANG Yan |
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| Affiliation: | ZHANG Li-Cheng,GUO Kun-Yuan,WANG Yan.Department of Hematology,Zhujiang Hospital,The First Military Medical University,Guangzhou 510282,China |
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| Abstract: | Objective:To investigate the effects of TJU103 on T lymphocytes proliferation and cytokine production in vitro.Methods:MTT and ELISA assays were used respectively to detect the proliferation and the cytokine production of donor T lymphocytes blocked by TJU103.Results:There are significant difference in the inhibition of T-cell proliferation and the cytokine production between groups of with TJU103 or without.Conclusion:TJU103 could significantly inhibit the T-cell proliferation and the cytokine production. |
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| Keywords: | TJU103 T cells Proliferation Cytokine |
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