住院儿柯萨奇病毒B组感染状况的分析

目的：分析近3年院内柯萨奇病毒B组感染状况，认识柯萨奇病毒B组与小儿疾病的内在关系。方法：观察了796例病儿，其中上呼吸道感染218例、肺炎179例、哮喘106例、心肌炎155例、紫癜19例，其他疾病89例，采用ELISA方法检测柯萨奇病毒B组（CVB）的抗原（CVB－Ag)和抗体IgM(CVB-IgM)。结果：（1）上呼吸道感染组和肺炎组CVB阳性率分别是47．25％和48．04％，两组间无统计学差异；（2）哮喘、心肌炎和紫癜儿CVB阳性率分别是62．265、61．25％和68．42％，三组间比较无统计学差异，但CVB阳性率均高于上呼吸道感染组和肺炎组（P＜0．05）；（3）其他疾病组和健康儿CVB感染发生率均低（分别是15．73％和3．33％），两组间无差异。结论：CVB感染与小儿多种疾病相关，尤其应该重视研究CVB感染与哮喘、病毒性心肌炎和过敏性紫癜发病的内在联系。

Analyzing the infectious state of coxsackievirus B in hospitalized children

Objective: To understand the relationship between coxsackievirus B and pediatric diseases. Methods: The infectious state of coxsackievirus B in hospitalized children were studied. Among 796 children studied, there were 218 upper respiratory tract infection cases, 179 pneumonia, 106 asthma, 155 myocarditis, 19 allergic purpura and 89 other diseases. The antigen (CVB Ag) and IgM (CVB IgM) were detected using ELISA method. Results: (1)There were 47% positive of CVB in upper respiratory tract infection and 48% positive of CVB in pneumonia(no difference between them, P >0.05). (2) There were 62% positive of CVB in asthma, 61% positive of CVB in myocarditis and 68% positive of CVB in allergic purpura(no difference among them, P >0.05); But the positive rate of CVB in asthma, myocarditis and purpura were higher than in upper respiratory tract infection and pneumonia, ( P <0.05). (3) There were lower positive rate of CVB in other kinds of diseases (16%) and in healthy children (3%)(no difference between them, P >0.05). Conclusion: CVB infection was related to several kinds of diseases, the relationship between CVB infection and diseases such as asthma, myocarditis, and allergic purpura should be further studied.