Stability of andrographolide in powdered Andrographis herb under accelerated conditions |
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Authors: | Plubrukarn Anuchit Pinsuwan Sirirat Ingkatawornwong Suthimaln Supavita Tanomjit |
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Institution: | Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand. |
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Abstract: | The stability of andrographolide in powdered Andrographis Herb--the aerial part of Andrographis paniculata (Burm. f.) Nees (Acanthaceae)--was determined using a heat-accelerated experiment to reveal a second-order kinetics of degradation. The fast decomposition was observed regardless of the method of analysis. The rate constant of the decomposition of andrographolide at 25 degrees C ( K(25)( degrees C)), predicted from the Arrhenius plot, was 6.58 x 10 (-6) d (-1). |
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