| 塞替派诱发人支气管上皮恶性转化成瘤细胞的生物学特性 |
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| 引用本文： | 周喆,袁素波,廖明阳. 塞替派诱发人支气管上皮恶性转化成瘤细胞的生物学特性[J]. 中国药理学与毒理学杂志, 2005, 19(2): 133-136 |
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| 作者姓名： | 周喆 袁素波 廖明阳 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 摘 要： | 目的 为进一步阐明化学致癌剂的作用机制提供实验依据。方法 利用原代细胞培养,细胞免疫化学分析获得并鉴定恶性转化成瘤细胞,以BEAS 2B细胞和BEAS STE细胞为参照,研究恶性转化成瘤细胞的增殖动力学和锚着独立生长能力等表型特征。结果和结论 经原代细胞培养获得可传代的具人类上皮来源的恶性转化成瘤细胞,恶性转化成瘤细胞较成瘤前细胞具有更强的恶性转化表型
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| 关 键 词： | 塞替派 转化,上皮细胞 肿瘤细胞,培养的 |
| 收稿时间： | 2004-10-30 |
Biological characteristics of tumorigenic human bronchial epith elial cells induced by thiotepa |
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| ZHOU Zhe,YUAN Su-Bo,LIAO Ming-Yang. Biological characteristics of tumorigenic human bronchial epith elial cells induced by thiotepa[J]. Chinese Journal of Pharmacology and Toxicology, 2005, 19(2): 133-136 |
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| Authors: | ZHOU Zhe YUAN Su-Bo LIAO Ming-Yang |
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| Affiliation: | (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China) |
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| Abstract: | AIM To provide the experimental evidences for explaining the mechamism of chemical tumorigenesis. METHODS Three tumorigenic cell lines derived from tumor tissues were established. Using the BEAS-2B and BEAS-STE cells as control, the dynamics of proliferation and anchorage independence growth of the BEAS-TT cells were studied. RESULTS and CONCLUSION The proliferation rate of the three BEAS-TT cells is slower than BEAS-2B and BEAS-STE cells. The anchorage independence growth capacity of BEAS-TT cells is stronger than BEAS-STE. |
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| Keywords: | thiotepa transformation epithelial cell tumor cells cultured |
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