疏血通注射液对心房颤动患者血栓前状态的影响

目的研究疏血通注射液对心房颤动患者血栓前状态的改善作用。方法将63例心房颤动患者随机分为疏血通组和对照组,疏血通组应用疏血通注射液治疗14d,对照组除不使用疏血通,其他用药与疏血通组相同。治疗前和治疗2周后测量两组血浆纤溶酶原激活物(tPA)及其抑制物(PAI-1)活性,D-二聚体(D-D)和血管性假血友病因子(vWF)水平。结果疏血通组和对照组在治疗前血浆tPA、PAI-1活性、D-D和vWF水平无统计学意义(P>0.05)。疏血通组治疗后血浆tPA活性显著性增高(P<0.05),血浆PAI-1活性、D-D和vWF水平均显著性下降(P<0.05),而对照组无显著性改变(P>0.05)。组间比较发现,疏血通组治疗后血浆PAI-1活性、D-D和vWF水平比对照组更低(P<0.05),而血浆tPA活性无显著增高(P>0.05)。结论短期疏血通静脉输注可以明显改善心房颤动患者的血栓前状态,这可能降低心房颤动患者的血栓栓塞危险。

Effect of Shuxuetong Injection on Prethrombotic State in Patients with Atrial Fibrillation

Objective To investigate the effect of Shuxuetong injection on prethrombotic state in patients with atrial fibrillation.Methods Sixty-three patients (pts) with atrial fibrillation were randomly divided into Shuxuetong group treated with Shuxuetong injection for two weeks and control group.Plasma tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) activity,D-dimer(D-D) and von willebrand factor (vWF) level were measured before and 2 weeks after treatment.Results There were no significant differences in the activity of tPA,PAI-1,D-D and vWF level before treatment in 2 groups (P>0.05).Shuxuetong group had significantly lower PAI-1 activity,D-D and vWF level than that in control group after treatment (P<0.05),but there was no significant difference in tPA activity(P>0.05).In Shuxuetong group,plasma tPA activity significantly increased (P<0.05),PAI-1 activity,D-D and vWF level significantly decreased after treatment (P<0.05),There were no significant differences in control group (P>0.05).Conclusion Shuxuetong injection could improve prethrombotic state in pts with atrial fibrillation and this might contribute to decrease risk of thrombosis.