| 中国乌头之研究——ⅩⅪ.赣皖乌头的研究 |
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| 引用本文： | 蒋山好,朱元龙,赵志扬,朱任宏.中国乌头之研究——ⅩⅪ.赣皖乌头的研究[J].药学学报,1983,18(6):440-445. |
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| 作者姓名： | 蒋山好 朱元龙 赵志扬 朱任宏 |
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| 作者单位： | 中国科学院上海药物研究所;*上海中医学院 |
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| 摘 要： | 从赣皖乌头(Aconitum finetianum Hand-Mazz)中又分得五个生物碱,经光谱及化学方法鉴定,其中二个为新的二萜类生物碱,即脱乙酰冉乌头碱(N-deacetylranconitine),C30H42N2O6,熔点125～127℃,和脱乙酰赣乌碱(N-deacetylfinaconitine),C30H42N2O9,熔点121～123℃,及三个已知生物碱,即阿娃乌头碱(avadharidine)、牛扁次碱(lycoctonine)和脱乙酰刺乌头碱(N-deacetyllappaconitine)。经药理试验表明,脱乙酰冉乌头碱,脱乙酰赣乌碱和脱乙酰刺乌头碱均具有良好的镇痛效果。
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| 关 键 词： | 赣皖乌头 生物碱 脱乙酰冉乌头碱 脱乙酰赣乌碱 脱乙酰刺乌头碱 阿娃乌头碱 牛扁次碱 镇痛效果 |
| 收稿时间： | 1982-03-08 |
Studies on a Chinese drug, Aconitum spp. XXI. Alkaloids from Aconitum finetianum Hand-Mazz |
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| Jiang Shan-hao,Zhu Yuan-long,Zhao Zhi-yang and Zhu Ren-hong.Studies on a Chinese drug, Aconitum spp. XXI. Alkaloids from Aconitum finetianum Hand-Mazz[J].Acta Pharmaceutica Sinica,1983,18(6):440-445. |
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| Authors: | Jiang Shan-hao Zhu Yuan-long Zhao Zhi-yang and Zhu Ren-hong |
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| Abstract: | Two new alkaloids, N-deacetylranaconitine, C30H42N2O8, mp 125～127℃; and Ndeacetylfinaconitine, C30H42N2O9, mp.121—123℃, and three known alkaloids, avadharidine, lycoctonine and N-deacetyllappaconitine have been isolated from the root of Aconitum finetianum Hand-Mazz.The chemical structures of N-deacetylranaconitine and N-deacetylfinaconitine were estabished by UV, IR, NMR and MS spectral data and chemical evidences.In animal experiments, N-deacetylranaconitine, N-deacetylfinaconitine and N-deacetyllappaconitine exhibited strong analgesic activity. |
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| Keywords: | Alkaloid N-Deacetylranaconitine: N-Deacetylfinaconitine N-Deacetyllappaconitine Avadharidine Lycoctonine Analgesic Aconitum finetianum Hand-Mazz |
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