荞麦红曲对实验性高脂血症小鼠血脂水平的影响

目的]探讨荞麦红曲对实验性高脂血症小鼠血脂水平的影响.方法]通过高脂高胆固醇饲料喂养2周,建立实验性高脂血症小鼠模型,同时灌胃给予小、中、大剂量荞麦红曲,测定各组小鼠血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平.结果]与高脂模型组比较,荞麦红曲中、大剂量组小鼠血清TG,TC和LDL-C水平均显著降低,HDL-C水平显著升高,荞麦红曲小剂量组小鼠血清TG和LDL-C水平显著降低.结论]荞麦红曲具有降低实验性高脂血症小鼠血脂的作用,对高脂血症具有一定的预防作用.

Effects of buckwheat monascus for experimental hyperlipidemia in mice

OBJECTIVE To investigate the effects of buckwheat monascus for experimental hyperlipidemia in mice.METHODS Experimental hyperlipidemia mouse models were established by feeding with high fat and cholesterol diet for 2 weeks and administrated by oral with high,medium and low doses of the buckwheat monascus,respectively,and the contents of TG,TC,HDL-C and LDL-C in serum were detected in each group of mice.RESULTS The medium and high doses of buckwheat monascus could significantly reduce the contents of TG,TC,and LDL-C and increase the contents of HDL-C in hyperlipidemia mice,and the low dose of buckwheat monascus could decrease the contents of TG and LDL-C.CONCLUSION The buckwheat monascus has the effects of marked decreasing the bloodlipid in experimental hyperlipidemia mice,and also has certain precautionary effects on hyperlipidemia.