早期血液灌流治疗急性重度氧化乐果中毒68例临床观察

目的探讨早期血液灌流治疗急性重度氧化乐果中毒的效果。方法选取急性重度氧化乐果中毒患者68例随机分为灌流组（HP组）34例和非灌流组（非HP组）34例,全部患者均进行常规内科治疗,HP组在此基础治疗上加用血液灌流,比较2组患者胆碱酯酶（ChE）活力恢复时间,阿托品应用总量,反跳发生率,中间综合症（IMS）发生率及病死率。结果 HP组ChE恢复时间,阿托品应用总量,反跳发生率,中间综合症（IMS）发生率及病死率均明显低于非HP组（P〈0.05）。结论早期血液灌流能迅速清除体内毒物,缩短ChE恢复时间,减少阿托品用量,降低反跳及IMS征的发生率,提高急性重度氧化乐果中毒抢救成功率。

Clinical observation of acute severe omethoate poisoning treated with early hemoperfussion

Objective To investigate the effect of early hemoperfusion on acute severe omethoate poisoning.Methods 68 patients with acute severe omethoate poisoning were randomly divided into hemoperfusion group（HP group,34 patients） and non-hemoperfusion group（NHP group,34 patients）.All patients were treated with routine treatment and Hp group with hemoperfussion,additionally.The recovery time of cholinesterase（CHE）,the dosage of atropine,the incidence of bounce and the occurrence rate or fatality fate of Intermediate syndrome（IMS） were observed.Results Compared with NHP group,HP group could have shortened CHE recovery time and reduced dosage of atropine.The incidence of bounce,the occurrence rate of atropine application,the incidence of bounce,and the occurrence rate or fatality rate of IMS of HP group were lower than that of NHP group（P0.05）.Conclusion Hemoperfussion at early stage can rapidly eliminate internal poison,shorten CHE recovery time,lessen dosage of atropine,lower the incidence of bounce and IMS and enhance success rate of salvage therapy of acute severe omethoate poisoning.