| 前列腺素E1对大鼠急性心肌梗死血管内皮生长因子表达的影响 |
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| 引用本文： | 李元.前列腺素E1对大鼠急性心肌梗死血管内皮生长因子表达的影响[J].现代预防医学,2011,38(19):3985-3986. |
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| 作者姓名： | 李元 |
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| 作者单位： | 山东省聊城市人民医院血管外科,聊城,252002 |
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| 摘 要： | 目的]探讨前列腺素E1(PGE1)对急性心肌梗死(AMI)大鼠心肌血管内皮生长因子(VEGF)表达的影响。方法]健康雄性SD大鼠50只分为PGE1处理组(n=40)、生理盐水对照组(n=10)和假手术组(n=10),PGE1处理组分为4个亚组,每组10只,分别采用不同剂量PGE1每日静脉注射,手术后2周和4周处死大鼠,取心脏标本切片,HE染色及VEGF免疫组化染色后显微镜观察,分析心肌VEGF蛋白表达水平。结果]PGE1处理组VEGF蛋白的表达显著增加,明显高于对照组和假手术组,差异有统计学意义(P﹤0.05)。随着PGE1剂量的增加,VEGF蛋白表达水平逐渐升高。结论]PGE1可以增加AMI大鼠心肌VEGF蛋白表达,促进侧支循环建立。PGE1引起的心肌VEGF蛋白表达升高作用呈剂量依赖性。
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| 关 键 词： | 心肌梗死 前列腺素E1 血管内皮生长因子 |
EFFECTS OF PGEI ON THE EXPRESSION OF VEGF IN RATS'CARDIAC MYOCYTES |
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| LI Yuan.EFFECTS OF PGEI ON THE EXPRESSION OF VEGF IN RATS'CARDIAC MYOCYTES[J].Modern Preventive Medicine,2011,38(19):3985-3986. |
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| Authors: | LI Yuan |
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| Institution: | LI Yuan.(Department of Vascular Surgery,the People's Hospital of Liaocheng City,Liaocheng 252002,China) |
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| Abstract: | Objective]To explore the effect of intravascular administration of prostaglandin E1(PGE1)on the expression of vascular endothelial growth factor(VEGF)in rats with acute myocardial infarction.Methods]Fifty healthy SD rats were randomized into treatment group(n = 40),control group and sham operation group.Rat AMI models were established.The treatment group was given various doses of PGE1 intravenously for 2 and 4 weeks while the control group and the sham operation group were given normal saline(NS)intraven... |
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| Keywords: | Acute myocardial infarction Prostaglandin E1 Vascular endothelial growth factor |
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