| 新生儿乙肝母婴阻断免疫策略及相关因素研究 |
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| 引用本文： | 赵捷,单芙香,刘刚.新生儿乙肝母婴阻断免疫策略及相关因素研究[J].现代预防医学,2011,38(15):2954-2955,2957. |
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| 作者姓名： | 赵捷 单芙香 刘刚 |
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| 作者单位： | 1. 南方医科大学附属深圳妇幼保健院,深圳,518028
2. 深圳市疾病预防控制中心 |
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| 摘 要： | 目的]探讨不同免疫策略对乙肝母婴阻断成功率的影响,为制定乙肝防控策略提供科学依据。方法]从医院收集2007~2009年HBsAg阳性产妇及其新生儿基本资料,采集儿童静脉血2ml,ELISA法检测乙肝表面抗原和表面抗体。将乙肝母婴阻断的免疫策略分成A组(孕晚期接种HBIG+儿童出生后接种HBIG+乙肝疫苗)、B组(儿童出生后接种乙肝免疫球蛋白+乙肝疫苗)、C组(乙肝疫苗)3组,比较不同免疫策略的乙肝母婴阻断成功率。结果]不同免疫策略乙肝母婴阻断成功率不同,A、B两组无差别,但均高于C组(χ2=6.64,P=0.01)。在调查的312名母亲HBsAg阳性的儿童中,乙肝母婴阻断成功率为95.53%(299/313),影响乙肝母婴阻断成功的因素包括分娩方式和母亲是否为乙肝大三阳。结论]分娩时尽量选择剖宫产,出生后联合接种乙肝免疫球蛋白和乙肝疫苗的策略会提高乙肝母婴阻断成功率。
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| 关 键 词： | 乙型肝炎 母婴阻断 免疫 |
STUDY ON RELATED FACTORS AND IMMUNIZATION STRATEGIES OF NEWBORN IN PREVENTING MOTHER-TO-CHILD TRANSMISSION OF HEPATITIS B |
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| ZHAO Jie,SHAN Fu-xiang,LIU Gang.STUDY ON RELATED FACTORS AND IMMUNIZATION STRATEGIES OF NEWBORN IN PREVENTING MOTHER-TO-CHILD TRANSMISSION OF HEPATITIS B[J].Modern Preventive Medicine,2011,38(15):2954-2955,2957. |
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| Authors: | ZHAO Jie SHAN Fu-xiang LIU Gang |
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| Institution: | ZHAO Jie,SHAN Fu-xiang,LIU Gang.(The Affiliated Shenzhen Maternity and Child Healthcare Hospital of The South Medical University in Guangdong province,Shenzhen 518048,China) |
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| Abstract: | Objective]To study the influential factors of immunization strategies in preventing mother-to-child transmission of(PMTCT)hepatitis B and to provide scientific basis of prevention and control strategies for the development of hepatitis B.Methods]Collected basic information of HBsAg-positive mothers and their newborns,from the hospital from 2007 to 2009,and 2ml navel blood were collected from the infants to detect hepatitis B virus infection by ELISA. Three kinds of immunization strategies of PMTCT were di... |
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| Keywords: | Hepatitis B PMTCT Immunization |
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