| 社区轻度认知功能障碍老年人认知减退转归结果分析 |
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| 引用本文： | 马菲,王婷,银炯,苗汝娟,张晓东,孟珺,张彩萍.社区轻度认知功能障碍老年人认知减退转归结果分析[J].现代预防医学,2011,38(19):3869-3871. |
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| 作者姓名： | 马菲 王婷 银炯 苗汝娟 张晓东 孟珺 张彩萍 |
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| 作者单位： | 1. 天津医科大学流行病教研室,天津,300070
2. 山西医秘大学流行病教研室 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的]了解轻度认知功能障碍(MCI)向认知减退转归结局及转化率,为预防痴呆发生提供可控制方案。方法]采用整群随机抽样方法调查社区65岁以上老年人6192人,根据DSM-IV标准,在基底人群中筛选600MCI对象,年龄±2岁、性别相同、文化程度一致的原则选取正常对照组,与MCI组进行1︰1匹配,按半年1次随访计划,完成3次随访。按照人年法计算发病密度及比较转化为认知减退RR和95%CI,采用Log-rank检验对每一指标不同水平随访对象认知减退转归比较。结果]565对研究对象纳入研究,认知减退组人年发病密度14.70%(14.52%,15.29%),正常对照组3.75%(3.56%,3.67%),两组随访对象转化为认知减退结局的生存曲线经Log-rank检验差异有统计学意义(χ2=11.643,P﹤0.01)。结论]MCI转化为认知减退结局的危险性远远大于认知正常受试者。提示对社区MCI人群早期干预可能对认知减退甚至老年痴呆预防起到重要作用。
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| 关 键 词： | 轻度认知功能障碍 认知减退 老年人 队列研究 |
THE RESEARCH ON THE CONVERSION TO THE OUTCOME OF COGNITIVE DECLINE IN MCI SUBJECTS AMONG COMMUNITY-BASED ELDERLY POPULATION |
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| MA Fei,WANG Ting,YIN Jiong,et al..THE RESEARCH ON THE CONVERSION TO THE OUTCOME OF COGNITIVE DECLINE IN MCI SUBJECTS AMONG COMMUNITY-BASED ELDERLY POPULATION[J].Modern Preventive Medicine,2011,38(19):3869-3871. |
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| Authors: | MA Fei WANG Ting YIN Jiong |
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| Institution: | MA Fei,WANG Ting,YIN Jiong,et al.(Department of Epidemiology,School of Public Health,Tianjin Medical University,Tianjin 300070,China) |
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| Abstract: | Objective]To understand the conversion to the outcome of cognitive decline in MCI and provide controllable scheme for the prevention of dementia.Methods]By cluster random sampling,6 192 aged people over 65 were ultimately involved.According to DSM-IV,600 subjects with MCI were screened from the baseline population.Each case was matched with one control by age decade,education and gender.The follow-up interviews were performed twice a year,totally three times.According to the follow-up information,incidenc... |
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| Keywords: | MCI Cognitive decline Aged people Cohort study |
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