| 硼替佐米、地塞米松联合治疗多发性骨髓瘤的临床疗效观察 |
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| 引用本文： | 陈蓓莉,林文远,王晓桃,刘冯,莫东华.硼替佐米、地塞米松联合治疗多发性骨髓瘤的临床疗效观察[J].现代预防医学,2011,38(16):3354-3356. |
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| 作者姓名： | 陈蓓莉 林文远 王晓桃 刘冯 莫东华 |
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| 作者单位： | 广西桂林市医学院附属医院.桂林,541001 |
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| 摘 要： | 目的]探讨硼替佐米、地塞米松联合治疗多发性骨髓瘤的临床疗效及安全性。方法]选取2008年6月~2009年12月在我科经硼替佐米联合地塞米松(VD)治疗的多发性骨髓瘤(MM)患者16例作为VD组,并选取同期在我科经VAD(长春瑞宾+阿霉素+地塞米松)治疗的25例MM患者作为VAD组,观察两组治疗效果及安全性,并对VD治疗方案在初治和复发患者中疗效、轻链型和非轻链型患者中的疗效进行对比分析。结果]VD组总有效率为87.50%,明显高于VAD组的48.00%,组间比较差异有统计学意义(P﹤0.05);VD组在初治和复发MM患者中疗效相当,在轻链型患者中CR率高于非轻链型患者;VD组不良反应轻微,均为可逆性。结论]VD化疗方案治疗MM,具有疗效好、不良反应小等优点,是目前治疗MM的一种较佳化疗方案,值得临床推广应用。
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| 关 键 词： | 硼替佐米 地塞米松 多发性骨髓瘤 化疗 |
THE OBSERVATION OF THE CLINICAL EFFECT OF BORTEZOMIB AND DEXAMETHASONE TO MULTIPLE MYELOMA |
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| CHEN Bei-li,LIN Wen-yuan,WANG Xiao-tao,et al..THE OBSERVATION OF THE CLINICAL EFFECT OF BORTEZOMIB AND DEXAMETHASONE TO MULTIPLE MYELOMA[J].Modern Preventive Medicine,2011,38(16):3354-3356. |
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| Authors: | CHEN Bei-li LIN Wen-yuan WANG Xiao-tao |
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| Institution: | CHEN Bei-li,LIN Wen-yuan,WANG Xiao-tao,et al.(Affiliated Hospital of Guilin Medical College,Guilin 541001,China) |
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| Abstract: | Objective]To evaluate the clinical efficacy and safety of bortezomib and dexamethasone to multiple myeloma.Methods]16 patients with nultiple myeloma(MM)treated in our department with bortezomib and dexamethasone(VD)during June 2008 - December 2009 were selected to be as the VD group,and 25 cases with MM treated in our department during the same period with VAD(vinorelbine + doxorubicin + dexamethasone)were selected to be as the VAD group. The effects and safety were observed,and the therapeutic effect was... |
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| Keywords: | Bortezomib Dexamethasone Multiple myeloma Chemotherapy |
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